Clinical characteristics of patients with community-acquired pneumonia caused by methicillin-sensitive Staphylococcus aureus versus Streptococcus pneumoniae
10.16718/j.1009-7708.2025.05.004
- VernacularTitle:甲氧西林敏感金黄色葡萄球菌与肺炎链球菌致社区获得性肺炎患者的临床特征分析
- Author:
Lu CHEN
1
;
Xin SHANG
Author Information
1. 南阳市第一人民医院呼吸危重症医学科,河南南阳 473000
- Publication Type:Journal Article
- Keywords:
methicillin-sensitive Staphylococcus aureus;
Streptococcus pneumoniae;
community-acquired pneumonia
- From:
Chinese Journal of Infection and Chemotherapy
2025;25(5):505-510
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare and analyze the clinical characteristics and outcomes of community-acquired pneumonia(CAP)caused by methicillin-sensitive Staphylococcus aureus(MSSA)and CAP caused by Streptococcus pneumoniae.Methods A prospective observational study was conducted on 870 patients with CAP diagnosis who were hospitalized during the period from February 2019 to January 2023.The patients were assigned to MSSA or S.pneumoniae group according to the primary pathogen of CAP.The clinical characteristics and outcomes of patients were compared between groups.Results Overall,51 patients with MSSA CAP and 819 patients with S.pneumoniae CAP were included in this study.Fever was reported in 62.75％(32/51)of patients with MSSA-CAP and 79.49％(651/819)of patients with S.pneumoniae CAP.Compared to S.pneumoniae,MSSA was associated with longer hospital stay(OR=2.016,P=0.016),longer ICU stay(OR=1.829,P=0.004),more ICU admission(OR=3.024,P＜0.001),more mechanical ventilation(OR=2.243,P=0.002),higher mortality within 30 days of admission(OR=2.623,P＜0.001),and higher mortality within 1 year after onset(OR=2.779,P=0.033).Conclusions The clinical symptoms of patients with MSSA CAP are relatively mild,but the outcome is worse than the patients with S.pneumoniae CAP.
