The Potential and Challenges of FGF9 as a Cancer Therapeutic Target
10.13241/j.cnki.pmb.2025.15.021
- VernacularTitle:FGF9作为癌症治疗靶点的潜力与挑战
- Author:
Qing ZHANG
1
;
Hong-yan HE
1
;
Jun-hua HUANG
1
;
Xin-yu LU
1
;
Hai-yan LI
1
Author Information
1. 西安医学院医学技术学院 陕西西安 710000
- Publication Type:Journal Article
- Keywords:
FGF9;
Cancer;
Functional mechanism;
Targeted diagnosis;
Research progress
- From:
Progress in Modern Biomedicine
2025;25(15):2554-2560
- CountryChina
- Language:Chinese
-
Abstract:
Fibroblast growth factor,as a critical protein regulating cell growth and differentiation,exhibits aberrant signaling closely associated with various pathological pathologies,including cancer.Among the members of the fibroblast growth factor family,fibroblast growth factor 9(FGF9)has been identified as a critical player in cancer initiation and progression.While numerous studies have investigated the molecular mechanisms of FGF9 individually,comprehensive reviews addressing its impact in cancer remain scarce.This article systematically reviews the functional mechanisms and regulatory networks of FGF9 in cancer,with a focus on its roles in common malignancies such as lung cancer,liver cancer,gastric cancer,colorectal cancer,breast cancer,and ovarian cancer.The aim is to facilitate translational research on FGF9 for targeted cancer diagnosis and therapy.
