The Role of Impulsivity in Cognitive Impairment in Manic Episodes of Bipolar Ⅰ Disorder
10.13241/j.cnki.pmb.2025.15.015
- VernacularTitle:冲动性在双相Ⅰ型障碍躁狂发作患者认知功能损害中的作用
- Author:
Jie LI
1
;
Mi-liang SHI
;
Gen-xiang PEI
;
Xu-dong LI
;
Ai-hong ZHANG
Author Information
1. 天水市第三人民医院精神科 甘肃天水 741000
- Publication Type:Journal Article
- Keywords:
Cognitive function;
Impulsiveness;
Bipolar disorder;
Type Ⅰ;
Manic episode
- From:
Progress in Modern Biomedicine
2025;25(15):2511-2516,2529
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the role of impulsivity in cognitive impairment in manic episodes of bipolar Ⅰ disorder(BPDTI)patients.Methods:180 cases of patients with BPDTI manic episodes admitted to our hospital from February 2024 to December 2024 were selected as the manic group,and another 180 cases of volunteers who were psychologically tested as normal during the same period were selected as the healthy group.The impulse Barratt-11 scale(BIS-11)and the MATRICS Consensus Cognitive Test(MCCB)were used to investigate and evaluate impulsivity and cognitive function,and correlation analysis and risk factor analysis were conducted.Results:In the BIS-11 scale,there was no statistically significant difference between the two groups in the unplanned factor(P＞0.05),but there were significant differences compared between the two groups in cognitive,motor factors,and total score(P＜0.05).The MCCB scores of the manic group in information processing speed,working memory,word learning,visual learning,social cognition,reasoning and problem solving,and attention vigilance were significantly lower than those of the healthy group(P＜0.05).The relationship between BIS-11 total score and cognitive impulsivity factor and MCCB total score and word learning showed there were negative correlation(P＜0.05);The exercise factor in the BIS-11 scale were negatively correlated with the MCCB total score and working memory factor(P＜0.05);The unplanned factor in the BIS-11 scale showed there were negative correlation with the MCCB total score,word learning(P＜0.05),and information processing speed.BIS-11,the number of years of education was an influencing factor for BPDTI mania(P＜0.05).Conclusion:BPDTI mania patients had high impulsivity and cognitive impairment,high impulsivity and number of years of education were influencing factors for mania,high impulsivity affected cognitive function through corresponding brain regions,aggravating the condition.
