Monitoring of voriconazole blood concentration in elderly patients and analysis of influencing factors
10.16718/j.1009-7708.2025.05.001
- VernacularTitle:老年患者伏立康唑血药浓度监测及影响因素分析
- Author:
Ge LI
1
;
Lei QIAN
;
Lei WANG
;
Ranran WANG
;
Can WEI
;
Ling FANG
Author Information
1. 安徽医科大学第一附属医院药剂科,国家中医药管理局中药化学三级实验室,合肥 230022
- Publication Type:Journal Article
- Keywords:
elderly patient;
voriconazole;
blood concentration monitoring;
influencing factor
- From:
Chinese Journal of Infection and Chemotherapy
2025;25(5):487-492
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the factors influencing the blood concentration of voriconazole in elderly hospitalized patients and inform the probability of attaining the target concentration in clinical practice.Methods Patients aged ≥65 years who were hospitalized in the First Affiliated Hospital of Anhui Medical University from January 2022 to December 2023 and underwent voriconazole blood concentration monitoring were enrolled.Their voriconazole blood concentrations and clinical data were collected.The patients were grouped according to the target effective concentration 0.5-5.0 mg/L of voriconazole recommended by the Chinese Pharmacological Society guidelines.Multivariate logistic regression analysis was used to determine the factors affecting the rate of achieving the target concentration.Results The 202 enrolled patients included 139 males and 63 females.A total of 244 voriconazole blood concentrations were available.The median age of the patients was 74(range:65-95)years.Voriconazole blood concentration ranged from 0.08 to 13.38 mg/L.The average concentration was(4.10±2.45)mg/L.The target effective blood concentration of voriconazole was achieved in 65.35％(132/202)of the patients.Logistic regression results showed that the dosage regimen,body weight,and hypoproteinemia(albumin＜25 g/L)were the main factors affecting voriconazole blood concentration.Conclusions The dosing regimen,body weight,and hypoproteinemia are the main influencing factors of voriconazole blood concentration.Relevant factors should be fully considered in clinical medication to ensure the safety and effectiveness of voriconazole.
