Abnormal endometrial blood flow is a relatively independent risk factor for repeated embryo implantation failure
10.3760/cma.j.cn101441-20210815-00355
- VernacularTitle:子宫内膜血流异常是胚胎反复种植失败的相对独立风险因素
- Author:
Yubin LI
1
;
Sunxing HUANG
1
;
Jingdi YANG
1
;
Zengyan WANG
1
Author Information
1. 中山大学附属第一医院生殖医学中心 广东省生殖医学重点实验室，广州 510080
- Publication Type:Journal Article
- Keywords:
Endometrium;
Blood supply;
Embryo transfer;
Doppler, color;
Ultrasonic examination
- From:
Chinese Journal of Reproduction and Contraception
2022;42(11):1182-1186
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the endometrial blood flow in patients with recurrent implantation failure (RIF) and non RIF patients.Methods:A prospective cohort study was perfomed. Infertility patients who underwent frozen-thawed embryo transfer (FET) cycles in the Reproductive Medicine Center of the First Affiliated Hospital of Sun Yat-Sen University from February 2019 to July 2019 were included. Transvaginal color Doppler ultrasound was used to detect whether there was subendometrial blood flow in the endometrium of RIF patients (RIF group, n=85) and non-RIF patients (non-RIF group, n=17). The proportion of patients without endometrial blood flow signal was compared, as well as endometrial blood flow pulsatility index (PI) and resistance index (RI). Results:Compared with non-RIF group, the proportion of patients without endometrial blood flow signal detected by ultrasound was significantly increased in RIF group [34.12% (29/85) vs. 5.88% (1/17), P=0.020]. PI and RI values of RIF group were significantly higher than those of non-RIF group (0.895 9±0.182 0 vs. 0.779 1±0.271 9, P=0.048; 0.575 6±0.078 4 vs. 0.511 1±0.130 7, P=0.016). Univariate logistic regression analysis showed that endometrial blood flow was an independent risk factors for RIF ( P=0.045). Conclusion:Abnormal endometrial blood flow may be related to RIF, which may cause RIF by reducing the receptivity of endometrium to embryo.
