Analgesic Effect of Different Doses of Dexmedetomidine Combined with Propofol in Elderly Patients Undergoing Radical Thyroidectomy for Thyroid Cancer and its Impact on Cognitive Function
10.13241/j.cnki.pmb.2025.15.014
- VernacularTitle:不同剂量右美托咪定复合丙泊酚在老年甲状腺癌根治术中的镇痛效果及对认知功能的影响
- Author:
Chen XU
1
;
Xu-hua KONG
;
Dan GAO
;
Wan-jun LIU
;
Jun-bo LI
Author Information
1. 荆门市沙洋县人民医院普外科 湖北荆门 448200
- Publication Type:Journal Article
- Keywords:
Different doses;
Dexmedetomidine;
Propofol;
Elderly;
Radical thyroidectomy for thyroid cancer;
Analgesic effect;
Cognitive Function
- From:
Progress in Modern Biomedicine
2025;25(15):2504-2510
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the application effect of different doses of dexmedetomidine combined with propofol in elderly patients undergoing radical thyroidectomy for thyroid cancer.Methods:This study was a prospective study,102 elderly patients undergoing radical thyroidectomy for thyroid cancer at Shayang County People's Hospital of Jingmen from April 2022 to April 2024 were selected,they were randomly divided into low-dose group and high-dose group used random number table method,with 51 patients in each group.Low-dose group received propofol(2.0 mg/kg)combined with dexmedetomidine(loading dose 0.3 μg/kg)for anesthesia induction,while high-dose group received propofol(1.0 mg/kg)combined with dexmedetomidine(loading dose 0.6 μg/kg)for anesthesia induction.The postoperative recovery indicators,pain level,cognitive function,hemodynamic indicators[mean arterial pressure(MAP)and heart rate(HR)],and adverse reactions between two groups were compared.Results:Compared with high-dose group,low-dose group had shorter awakening time,spontaneous breathing recovery time,tracheal extubation time,and lower incidence of adverse reactions(P＜0.05).Compared with high-dose group at 6 h,12 h,and 24 h after surgery,low-dose group had lower pain visual analog scale(VAS)scores and higher mini-mental state examination(MMSE)scores(P＜0.05).Compared with high-dose group at separation of thyroid gland(T2)to completion of surgery(T3),low-dose group had lower MAP and HR(P＜0.05).Conclusion:Loading dose 0.3 μg/kg dexmedetomidine combined with propofol has a good analgesic effect in elderly patients undergoing radical surgery for thyroid cancer,it can also maintain hemodynamic stability,reduce the impact on cognitive function,and lower the incidence of adverse reactions.
