Research Progress on Molecular Markers Related to Invasion and Metastasis of Esophageal Squamous Cell Carcinoma
10.3969/j.issn.1008-7125.2025.02.007
- VernacularTitle:食管鳞状细胞癌侵袭、转移相关分子标志物的研究进展
- Author:
Liangliang ZHENG
1
;
Qiqi ZHANG
1
;
Zhiqiang ZHANG
1
Author Information
1. 新疆医科大学第一附属医院消化病二科(830054)
- Publication Type:Journal Article
- Keywords:
Esophageal Squamous Cell Carcinoma;
Invasion;
Neoplasm Metastasis;
Molecular Markers
- From:
Chinese Journal of Gastroenterology
2025;30(2):123-128
- CountryChina
- Language:Chinese
-
Abstract:
Esophageal squamous cell carcinoma(ESCC)has a poor prognosis,and its invasion and metastasis are the main cause of decreased patients'quality of life and survival rate.The invasion and metastasis of ESCC involve multiple mechanisms,including extracellular matrix degradation,epithelial-mesenchymal transition(EMT),and tumor angiogenesis,accompanied by molecular abnormalities at multiple levels,such as non-coding RNAs,EMT-related proteins,matrix metalloproteinases,vascular endothelial growth factor,exosomes,and circulating tumor cells.Predicting the risk of ESCC invasion and metastasis and implementing active interventions are crucial for effective treatment of ESCC and improvement of patients'quality of life and survival rate.This article reviewed the research progress on molecular markers related to invasion and metastasis of ESCC,aiming to provide insights for the early diagnosis and treatment of ESCC.
