Effects of Tetrandrine Tablets Combined with Montelukast Sodium on Respiratory Function,Inflammatory Mediators and Serum MMP-9 and bFGF Levels in Pneumoconiosis Patients
10.13241/j.cnki.pmb.2025.15.008
- VernacularTitle:汉防己甲素片联合孟鲁司特钠对尘肺病患者呼吸功能、炎性介质及血清MMP-9、bFGF水平的影响
- Author:
Yang-kun LIN
1
;
Ding-hui WU
1
;
Wei-ming SU
1
Author Information
1. 厦门大学附属第一医院杏林分院肺科 福建厦门 361000
- Publication Type:Journal Article
- Keywords:
Tetrandrine tablets;
Montelukast sodium;
Pneumoconiosis;
Respiratory function;
Inflammatory mediators;
Matrix metalloproteinase-9;
Basic fibroblast growth factor
- From:
Progress in Modern Biomedicine
2025;25(15):2458-2464
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effects of tetrandrine tablets combined with montelukast sodium on respiratory function,inflammatory mediators,serum matrix metalloproteinase-9(MMP-9)and basic fibroblast growth factor(bFGF)levels in pneumoconiosis patients.Methods:120 pneumoconiosis patients who were admitted to our hospital from January 2023 to June 2024 were selected,they were divided into control group(montelukast sodium treatment,n=60)and study group(tetrandrine tablets combined with montelukast sodium treatment,n=60)by random number table method.The pulmonary function indexes[first second forced expiratory volume(FEV1),forced vital capacity(FVC),maximum ventilation volume(MVV)],6-minute walking test(6MWT)disitance,St.George Respiratory Questionnaire(SGRQ)score,Improved Medical Research Council Dyspnea(mMRC)index,and inflammatory mediators[Cystatin C(Cys C),interleukin-2 receptor(IL-2R),C-reactive protein(CRP)]and serum MMP-9,bFGF levels were compared between the two groups.The occurrence of adverse reactions were observed.Results:FEV1,FVC,MVV,6MWT distance in the study group at 6 months after treatment were higher than those in the control group,and SGRQ score,mMRC index,CysC,IL-2R,CRP,MMP-9,bFGF were lower than those in the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion:Tetrandrine tablets combined with montelukast sodium in the treatment of pneumoconiosis patients can effectively improve respiratory function,increase exercise endurance,regulate inflammatory mediators and serum MMP-9,bFGF levels,which is safe and reliable.
