Prediction of the Risk of Ischemic Stroke Recurrence in Patients with Mild to Moderate Carotid Stenosis via Ultrasound Combined with Clinical Indicators
10.3969/j.issn.1005-5185.2025.09.012
- VernacularTitle:超声联合临床指标预测颈动脉轻-中度狭窄患者缺血性脑卒中复发风险
- Author:
Zhiying JIN
1
;
Ruilan NIU
;
Naiqin FU
;
Zhili WANG
Author Information
1. 南开大学医学院,天津 300071;解放军总医院第一医学中心超声诊断科,北京 100853
- Publication Type:Journal Article
- Keywords:
Carotid plaque;
Ultrasonography;
Contrast-enhanced ultrasound;
Ischemic stroke;
Recurrence;
Forecasting
- From:
Chinese Journal of Medical Imaging
2025;33(9):974-979
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To explore the value of gray-scale ultrasound and contrast-enhanced ultrasound of carotid plaques combined with clinical factors in predicting the recurrence risk of ischemic stroke(IS)in patients with mild to moderate carotid stenosis.Materials and Methods A total of 101 patients with mild to moderate carotid artery stenosis who were initially diagnosed with IS in the First Medical Center of the Chinese PLA General Hospital were prospectively collected from May 2022 to August 2023.After one year of follow-up,patients were divided into recurrent group(n=33)and non-recurrent group(n=68)according to whether new IS occurred.The characteristics of plaque ultrasound and the clinical information of patients were compared between the two groups.A multivariate Logistic prediction model was established and its efficacy was evaluated.Results The results of multivariate analysis showed that low-density lipoprotein cholesterol(OR=2.116,P=0.046),C-reactive protein(OR=3.707,P=0.008),plaque internal echo(OR=7.410,P=0.029)and intraplaque neovascularization grading 3(OR=17.155,P=0.030)were independent risk factors for the recurrence of IS.The area under the curve of the model established using the above indicators was 0.825,the sensitivity and specificity were 87.50%and 65.15%,respectively.Conclusion The ultrasound features of carotid plaque are closely related to recurrent IS,which can provide an important basis for the clinical treatment of patients with mild-moderate carotid artery stenosis complicated with IS.
