Duration of oral administration of estrogen does not affect the outcome of singleton offspring outcomes in single frozen blastocyst transfer cycles
10.3760/cma.j.cn101441-20220203-00052
- VernacularTitle:人工周期冻融单囊胚移植前口服雌激素时间不影响单胎子代出生结局
- Author:
Junwei ZHANG
1
;
Mingze DU
1
;
Jing LI
1
;
Pingping KONG
1
;
Wenjuan ZHANG
1
;
Lijun SUN
1
;
Yichun GUAN
1
Author Information
1. 郑州大学第三附属医院生殖医学科，郑州 450052
- Publication Type:Journal Article
- Keywords:
Infant, small for gestational age;
Frozen-thawed embryo transfer;
Artificial cycle
- From:
Chinese Journal of Reproduction and Contraception
2023;43(6):612-617
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore whether the duration of oral estrogen treatment before progesterone application affects neonatal outcome in single frozen-thawed embryo transfer (FET) with artificial cycles.Methods:It was a retrospective cohort study. Patients who underwent in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI), receiving single frozen blastocyst transfer with artificial cycle and delivering a single live birth in the Reproductive Center of the Third Affiliated Hospital of Zhengzhou University between January 2015 and December 2019 were included. All FET cycles were divided into four groups according to the estrogen treatment duration before progesterone application, ≤12 d ( n=306), 13-15 d ( n=620), 16-18 d ( n=471), and ≥19 d ( n=275). Primary outcome was the incidence of small for gestational age (SGA). Secondary outcomes were the incidence of preterm birth, low birth weight, macrosomia and large for gestational age (LGA). Results:A total of 1 672 single blastocyst transfer cycles were included. The incidence of SGA among the four groups was 7.8% (24/306), 4.8% (30/620), 5.7% (27/471), and 7.6% (21/275), respectively, with no statistically significant difference ( P=0.204). The results of multiple logistic regression analysis showed that the duration of estrogen used before progesterone application did not affect the incidence of SGA in singleton offspring (with ≤12 d as the reference, 13-15 d: a OR=1.37, 95% CI: 0.70-2.70, P=0.361; 16-18 d: a OR=0.74, 95% CI: 0.40-1.36, P=0.336; ≥19 d: a OR=0.81, 95% CI: 0.44-1.49, P=0.501). There were no significant differences in neonatal preterm birth rate ( P=0.204), low birth weight ( P=0.582), incidences of macrosomia ( P=0.201) and LGA infants ( P=0.335) among the four groups. Conclusion:In artificial FET cycle, the duration of oral estrogen treatment before progesterone application does not affect the outcome of singleton offspring after single blastocyst transfer.
