Genetic tests provide information and guidance for patients with repeated IVF/ICSI failures

VernacularTitle:基因检测为反复IVF/ICSI助孕失败患者提供理论参考
Author: Zhou ZHOU ¹ ; Qing SANG ; Lei WANG
Author Information

1. 复旦大学生物医学研究院，上海　200032
Publication Type:Journal Article
Keywords: Reproductive techniques, assisted; Genetic testing; Infertility; Genetic factors
From: Chinese Journal of Reproduction and Contraception 2023;43(1):37-41
CountryChina
Language:Chinese
Abstract: Infertility has become the third largest disease in the 21st century after cancer and cardiovascular diseases. Currently, assisted reproductive technology (ART) has become a routine treatment for infertility, whose success rate is only 30%-40%. Genetic or non-genetic factors affect the quality of sperm and oocytes retrieved from patients, leading to no viable embryos by in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI). In recent years, with the development of reproductive genetics and genetic tests, genetic tests are becoming increasingly relevant in reproductive medicine. The application of genetic tests in IVF/ICSI can help patients identify the infertility causes and guide a personalized diagnostic and therapeutic treatment approach. In this paper, the abnormal reproductive phenotypes discovered in ART, corresponding pathogenic genes and genetic testing were discussed in order to provide a new idea for the diagnosis and treatment of patients with repeated IVF/ICSI failures.