Clinical application value of polar body biopsy in preimplantation genetic testing
10.3760/cma.j.cn101441-20220831-00374
- VernacularTitle:极体活检在胚胎植入前遗传学检测中的临床应用价值
- Author:
Jia CHEN
1
;
Qiongfang WU
1
Author Information
1. 江西省妇幼保健院生殖医学中心，南昌 330006
- Publication Type:Journal Article
- Keywords:
Polar body;
Preimplantation genetic testing;
Biopsy;
Monogenic diseases;
Chromosomal aneuploidy;
Chromosomal structure rearrangement
- From:
Chinese Journal of Reproduction and Contraception
2022;42(11):1146-1151
- CountryChina
- Language:Chinese
-
Abstract:
Polar bodies are the byproducts of oocyte meiosis, which contain the corresponding genetic material with the egg cell. Genetic testing of the polar bodies can infer the chromosomal and genetic state of the corresponding egg cell. Polar body biopsy is a safe and effective method for preimplantation genetic testing (PGT), which has the characteristics of less damage to the embryo and easy to be accepted ethically. Polar body analysis is mainly used for PGT of maternal monogenic diseases, chromosomal aneuploidy and structure rearrangement, with significant advantages especially for the females with de novo mutations, absent of family members, and gonadal mosaic mutation, preventing the transmission of mitochondrial diseases, and screening chromosomal aneuploidy with advanced age. In addition, compared with blastocyst detection, preimplantation detection in the polar body stage avoids embryo waste caused by failure of blastocyst culturing, improves the utilization of embryos. This characteristic may take more advantages for females with ovarian insufficiency. Moreover, polar body biopsy moves the detection time forward and makes fresh embryo transfer available. This paper summarized the application of polar body biopsy in PGT aiming to reveal its clinical value.
