Immune-metabolic characteristics and the role of miRNA in decidual macrophage polarization at maternal-fetal interface
10.3760/cma.j.cn101441-20220413-00163
- VernacularTitle:母-胎界面miRNA对蜕膜巨噬细胞极化的调控作用
- Author:
Jing YANG
1
;
Linlin WANG
;
Yulin ZHAO
;
Shujuan WU
;
Lianghui DIAO
;
Longfei LI
;
Jiao CHEN
;
Jing YANG
Author Information
1. 武汉大学人民医院生殖医学中心 湖北省辅助生殖与胚胎发育医学临床研究中心，武汉 430060
- Publication Type:Journal Article
- Keywords:
Macrophage;
MicroRNA;
Polarization;
Maternal-fetal interface
- From:
Chinese Journal of Reproduction and Contraception
2023;43(9):974-981
- CountryChina
- Language:Chinese
-
Abstract:
Successful pregnancy requires a balanced immune environment at the maternal-fetal interface, which not only maintains immune tolerance to ensure fetal development, but also requires a moderate immune response to resist infection. The distribution and dynamic changes of macrophages in decidual tissue suggested that it plays an important role in immune regulation, such as influencing vascular remodeling, regulating trophoblast cell function and immune cell activity. MicroRNA (miRNA) is a class of small non-coding RNA involved in the occurrence and development of diseases, and its functions and mechanisms in tumor have been extensively studied. The regulatory role of miRNA in pregnancy, especially in decidual macrophage polarization, is complex. In this paper, we systematically analyzed the phenotypic distribution of decidual macrophages at the maternal-fetal interface, and suggested that the inhibition of M2 phenotype polarization or abnormal activation of M1 was associated with pregnancy complications. We further discussed the regulation of miRNA transcription in immune responses of macrophages and metabolic regulation of macrophage polarization. It was confirmed that abnormal miRNA expression led to adverse pregnancy. A full understanding of the molecular mechanisms of miRNA in inflammatory response and metabolism of decidual macrophages can provide a new insight to the clinical diagnosis and treatment of adverse pregnancy.
