Expression of MUM1 in endometrium of patients with recurrent implantation failure and its diagnostic value in chronic endometritis
10.3760/cma.j.cn101441-20220210-00059
- VernacularTitle:MUM1在反复种植失败患者子宫内膜中的表达及对其慢性子宫内膜炎的诊断价值
- Author:
Xiya LI
1
;
Dongmei ZHAO
;
Yaqin WANG
;
Li TAN
;
Jie ZHANG
;
Huifang WU
Author Information
1. 郑州大学第二附属医院生殖医学中心，郑州 450000
- Publication Type:Journal Article
- Keywords:
Multiple myeloma oncogene l;
Recurrent implantation failure;
Chronic endometritis;
Endometrium;
Immunohistochemistry staining;
Diagnostic value
- From:
Chinese Journal of Reproduction and Contraception
2023;43(1):73-77
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of multiple myeloma oncogene 1 (MUM1) in patients with recurrent implantation failure (RIF) and its diagnostic value in chronic endometritis (CE).Methods:The data of 112 patients with RIF treated in the Reproductive Medicine Centre of the Second Affiliated Hospital of Zhengzhou University from October 2019 to October 2021 were collected by cohort study. All patients underwent hysteroscopy, endometrial tissue was collected and the positive expressions of MUM1 and CD138 in endometrial tissue were detected by immunohistochemistry staining; the differences in the positive expression rates of MUM1 and CD138 in endometrium were compared; the consistency of hysteroscopy combined with MUM1 and combined with CD138 immunohistochemistry staining in the diagnosis of CE was compared by Kappa test; the sensitivity of MUM1 and CD138 in diagnosing CE was compared by four-tabular method.Results:There were 55 cases of CE diagnosed by hysteroscopy in 112 patients with RIF, and the incidence was 49.11%. The positive expression rate of MUM1 was higher than that of CD138 [52.68% (59/112) vs. 41.07% (46/112), P<0.001] in endometrium of 112 RIF patients; the Kappa value of hysteroscopy combined with MUM1 and combined with CD138 immunohistochemistry staining in the diagnosis of CE was 0.794; the sensitivity and negative predictive value of endometrial MUM1 immunohistochemistry staining in the diagnosis of CE were higher than those of CD138 [100% (59/59) vs. 77.97% (46/59) and 100% (53/53) vs. 80.31% (53/66), all P<0.001]. Conclusion:In patients with RIF, hysteroscopy combined with endometrial MUM1 immunohistochemistry staining can be used as a more accurate method for diagnosing CE.
