Participation of lysine lactylation in neuropsychiatric system disorders
10.3969/j.issn.1000-4718.2025.10.022
- VernacularTitle:赖氨酸乳酸化修饰在神经精神疾病相关认知障碍中的研究进展
- Author:
Qiang ZHU
1
;
Weishi CHEN
;
Dingding LIU
;
Guirong ZENG
Author Information
1. 贵州中医药大学中药民族药药性研究中心,贵州 贵阳 550025
- Publication Type:Journal Article
- Keywords:
lysine lactylation;
neuropsychiatric diseases;
cognitive disorders;
inflammation;
neuron
- From:
Chinese Journal of Pathophysiology
2025;41(10):2053-2058
- CountryChina
- Language:Chinese
-
Abstract:
Lysine lactylation is a type of histone post-translational modification that is mainly regulated by fac-tors such as lactate level,glycolysis level,and vario us enzymes and proteins.Lysine lactylation involves several physio-pathological activities,including macrophage inflammatory response,somatic cell reprogramming,neuronal activity,and embryonic development,etc.Changes in the level of lactfication modification are involved in the development of neuropsy-chiatric disorders such as Alzheimer disease(AD),schizophrenia(SCZ)and depression.Inflammatory response and ab-normal neuronal activity are one of the important causes of neuropsychiatric diseases.The change of lactfication modifica-tion level participates in the development of AD,SCZ,depression and other neuropsychiatric diseases,which specifically regulate neuronal apoptosis,neuronal excitation,and microglial inflammatory response.
