Progress in role of microbe-bile acid pathway in progression and treat-ment of intestinal inflammatory diseases
10.3969/j.issn.1000-4718.2025.00.008
- VernacularTitle:微生物-胆汁酸通路在肠道炎性疾病进程和治疗方面的研究进展
- Author:
Jinling MO
1
;
Jiamin DONG
;
Xinyi YANG
;
Wenting ZHANG
Author Information
1. 南通大学附属常州儿童医院,儿科中心实验室,江苏 常州 213000
- Publication Type:Journal Article
- Keywords:
bile acids;
receptors;
intestinal diseases;
intestinal microbiota
- From:
Chinese Journal of Pathophysiology
2025;41(10):2046-2052
- CountryChina
- Language:Chinese
-
Abstract:
Bile acids encompass primary bile acids and secondary bile acids,the latter of which are produced from primary bile acids in the gut.In recent years,bile acids,compounds with a steroid structure found in bile,have been shown through extensive clinical investigations and fundamental studies to play a significant role in regulating intestinal and systemic immune homeostasis,inflammatory responses,and neurological disorders.In the gut,primary and secondary bile acids can disrupt the invasion of pathogenic microorganisms into the host due to their unique physical properties.Additional-ly,they regulate downstream signaling pathways by binding to effector receptors,thereby performing vital biological func-tions,including the modulation of immune responses.Consequently,bile acids function as essential small molecules in the pathophysiological processes of various intestinal diseases and extra-intestinal tissue conditions influenced by intestinal homeostasis.This article focuses on the role and regulatory mechanisms of the"microbe-bile acid"axis in intestinal inflam-mation,elucidating the synthesis and metabolism of bile acids and the significance of intestinal microbes in signal trans-duction via bile acids during the inflammatory process.It aims to provide a foundation and reference for the development of drugs and therapeutic strategies targeting diseases related to intestinal inflammation and immune dysregulation.
