Progress in mechanism and clinical application of miRNA regulating os-teogenesis-angiogenesis coupling in SONFH
10.3969/j.issn.1000-4718.2025.10.019
- VernacularTitle:miRNA调控激素性股骨头坏死成骨-成血管耦联的机制及临床应用研究进展
- Author:
Haiyuan GAO
1
;
Mingwang ZHOU
;
Xiaoping WANG
;
Xing YANG
;
Zhenhua SHI
Author Information
1. 甘肃中医药大学,甘肃 兰州 730000
- Publication Type:Journal Article
- Keywords:
steroid-induced necrosis of the femoral head;
microRNA;
osteogenesis-angiogenesis coupling
- From:
Chinese Journal of Pathophysiology
2025;41(10):2030-2037
- CountryChina
- Language:Chinese
-
Abstract:
Steroid-induced osteonecrosis of the femoral head(SNOFH)is a prevalent challenging condition in orthopedics,characterized by a high disability rate and intricate pathophysiological mechanisms including diminished an-giogenesis and impaired osteogenic function.The concept of osteogenesis-angiogenesis coupling involves the interplay be-tween osteoblasts and angiogenesis.Restoring the blood supply to bone tissue,boosting bone cell activity,and facilitating bone regeneration are crucial for the recovery of SNOFH patients.Research has demonstrated the significant role of mi-croRNAs(miRNAs)in the coordination of osteogenesis and angiogenesis.MiRNAs have the ability to concurrently regu-late multiple target genes and signaling pathways associated with osteogenesis and angiogenesis,effectively stimulating the regeneration of bones and blood vessels.By considering the interaction of multiple miRNAs and their target genes,the de-velopment of a multi-target combination therapy approach could greatly enhance the treatment outcomes for SNOFH.Through a thorough investigation of miRNA interactions in the regulation of osteogenesis and angiogenesis,the progression of the disease can be elucidated,offering a fundamental basis for early diagnosis,precise treatment,and prognosis evalua-tion of SNOFH.This paper aims to uncover the pivotal nodes and regulatory connections in SNOFH by summarizing the in-volvement of miRNAs in the coupling of osteogenesis and angiogenesis.By identifying potential therapeutic targets and un-derstanding the coordinated function of miRNAs in osteogenesis and angiogenesis coupling,valuable insights can be gained for the personalized treatment of SNOFH.
