Progress in role of P2X4R in neuropathic pain caused by peripheral nerve injury
10.3969/j.issn.1000-4718.2025.10.018
- VernacularTitle:P2X4R在周围神经损伤所致神经病理性疼痛中作用的研究进展
- Author:
Yan WANG
1
;
Yahui WANG
;
Yan WANG
;
Fei PEI
;
Lijie LÜ
;
Tianyi LI
;
Shujin WANG
;
Huan QIN
Author Information
1. 黑龙江中医药大学,黑龙江 哈尔滨 150040
- Publication Type:Journal Article
- Keywords:
P2X4 receptor;
peripheral nerve injury;
neuropathic pain
- From:
Chinese Journal of Pathophysiology
2025;41(10):2023-2029
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,there has been a significant rise in the incidence of peripheral nerve injury(PNI),highlighting the urgent need for effective treatment strategies.The inflammation and pain hypersensitivity associated with PNI greatly diminish patients'quality of life.Although there are promising treatment approaches for nerve injury,the com-plex pathological mechanisms underlying neuropathic pain caused by PNI present significant challenges for clinical manage-ment.Extensive research has established that the development of neuropathic pain is closely linked to nerve conduction and related signaling molecules.Among these,P2X4 receptor(P2X4R),an ATP-dependent ion channel,is involved in nerve signal transmission and associated pathways-plays a crucial role in the progression of neuropathic pain.This article offers a comprehensive overview of the function and distribution of P2X4R,investigates its pathological mechanisms in PNI-induced neuropathic pain,and elucidates its relationship with peripheral neuropathic pain disorders.Through this explo-ration,we aim to provide valuable insights that could inform the development of novel clinical strategies for pain management.
