Unilateral adrenal aldosteronoma with Klinefelter syndrome:one case report and literature review
10.3969/j.issn.1672-8467.2025.05.019
- VernacularTitle:单侧肾上腺醛固酮瘤合并克氏综合征:1例报告并文献复习
- Author:
Yue LI
1
;
Shu-fei ZANG
;
Yue-yue WU
;
Bing-bing ZHA
;
Guo-wei SHI
;
Jun ZHANG
;
Jun LIU
Author Information
1. 复旦大学附属上海市第五人民医院内分泌科 上海 200240
- Publication Type:Journal Article
- Keywords:
primary aldosteronism(PA);
aldosteronoma;
Klinefelter syndrome(KS)
- From:
Fudan University Journal of Medical Sciences
2025;52(5):752-758
- CountryChina
- Language:Chinese
-
Abstract:
Primary aldosteronism(PA)is the most common cause of secondary hypertension,yet its diagnosis remains under-recognized,with a high rate of missed diagnoses.This condition significantly impacts multiple systems,including the cardiovascular,renal,metabolic,and skeletal systems,resulting in notable complications.Patients with Klinefelter syndrome(KS)exhibit a markedly higher prevalence of metabolic disorders,which may further exacerbate cardiovascular and endocrine dysfunction.Here we report a patient who presented with refractory hypertension and an incidentally discovered adrenal mass,and was ultimately diagnosed with a left adrenal aldosterone-producing adenoma combined with KS.We provide a detailed description of the patient's clinical manifestations,biochemical indices,diagnostic process,and postoperative histopathological findings in order to enhance the understanding of PA and KS and their potential interconnections,which offers diagnostic insights to reduce misdiagnosis and missed diagnoses.
