Two cases of unicornuate uterus with ectopic ovary in IVF-ET and literature review
10.3760/cma.j.cn101441-20201204-00660
- VernacularTitle:体外受精-胚胎移植中单角子宫并卵巢异位2例报道并文献复习
- Author:
Yaqin WANG
1
;
Qianrong QI
;
Wangming XU
;
Xiaoyan ZHOU
;
Jing YANG
Author Information
1. 武汉大学人民医院生殖医学中心，湖北省辅助生殖与胚胎发育医学临床研究中心，武汉 430060
- Publication Type:Journal Article
- Keywords:
Ectopic ovary;
Unicornuate uterus;
Controlled ovarian stimulation;
Oocyte pick up;
Embryo transfer
- From:
Chinese Journal of Reproduction and Contraception
2022;42(6):621-625
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To summarize the management of unicornuate uterus with ectopic ovary during in vitro fertilization and embryo transfer (IVF-ET). Methods:The clinical data of 2 rare cases of uniangular uterus with ectopic ovary undergoing IVF-ET were retrospectively analyzed and the related literatures were reviewed.Results:Two patients were diagnosed as unicornuate uterus with unilateral ovary missing by vaginal ultrasound, subsequent abdominal ultrasound and magnetic resonance imaging (MRI) results indicated follicular structure in the peritoneal area, suggesting ectopic ovary. Case 1 showed flank pain as well as discrepancy between serum estradiol level and follicle numbers during ovarian hyperstimulation. The patient received trans-abdominal combined with trans-vaginal oocyte retrieval and successfully delivered a healthy baby at 36 weeks by transferring frozen blastocyst embryo. Case 2 was diagnosed as unicornuate uterus with lateral ectopic ovary by abdominal ultrasound before IVF treatment. We performed synchronized monitoring of bilateral ovarian follicular development and oocytes retrieval by transabdominal and transvaginal ultrasound, and then the two blastocysts were cryopreserved. However, the patient experienced spontaneous abortion following single frozen-thawed blastocyst transfer.Conclusion:Ectopic ovaries present no obvious clinical manifestation and is easy to be ignored in diagnosis. For patients with unicornuate uterus treated by assisted reproductive technology, if vaginal ultrasound fails to detect ovary, we should further perform abdominal ultrasound or MRI to screen for ectopic ovary. If diagnosed with ectopic ovary, the patients should simultaneously be monitored the follicullar development of bilateral ovaries during the process of ovarian hyperstimulation and adopt both transabdominal and transvaginal ultrasound-guided follicular aspiration to maximize the numbers of oocyte and pregnancy chance.
