Prospective study on the association between lifestyles and the risk of type 2 diabetes in adult residents
10.3969/j.issn.1672-8467.2025.05.004
- VernacularTitle:成年居民生活方式与2型糖尿病发病风险关联的前瞻性研究
- Author:
Meng-ru HE
1
;
Xiao-li XU
;
Gen-ming ZHAO
;
Xing LIU
;
Hui-lin XU
;
Dan-dan HE
;
Yu-ping CHENG
;
Yong-gen JIANG
;
Qian PENG
;
Jian-hua SHI
;
Xiao-hua LIU
Author Information
1. 上海市闵行区疾病预防控制中心(上海市闵行区卫生健康监督所)上海 201101
- Publication Type:Journal Article
- Keywords:
lifestyle;
type 2 diabetes(T2D);
adult resident;
perspective study
- From:
Fudan University Journal of Medical Sciences
2025;52(5):647-656,685
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the association between lifestyle and the risk of type 2 diabetes(T2D)among adult residents.Methods The data was sourced from the Shanghai Suburban Adult Cohort and Biobank.A total of 42 096 adult residents who had not developed T2D were recruited from four districts of Shanghai(Songjiang,Jiading,Minhang,and Xuhui)between 2016 and 2019.The follow-up ended on Feb 28,2023.A structured questionnaire was used to collect information on six lifestyle-related items,including smoking,alcohol consumption,BMI,waist circumference(WC),physical activity,and diet.The unhealthy lifestyle scores(UHLS)were calculated by counting the number of all the unhealthy lifestyle items,with a range of 0-6.New-onset T2D events diagnosed by physicians were obtained through the medical information system.Cox proportional hazards regression model and restricted cubic spline model were utilized to evaluate the association between unhealthy lifestyles and the risk of T2D incidence.Results About 28.1%of the participants led 4-6 unhealthy lifestyles.A total of 1 752 new T2D cases were identified during 218 513.4 person-years of follow-up.Analysis of single unhealthy lifestyle showed that abnormal WC(HR=1.5,95%CI:1.4-1.7)and abnormal BMI(HR=1.3,95%CI:1.2-1.5)were associated with an increased risk of T2D.Compared with individuals with a UHLS of 0-1,those with a UHLS of 3 and 4-6 had 30%(95%CI:1.1-1.6)and 50%(95%CI:1.2-1.8)higher risks of T2D,respectively.Each additional unhealthy lifestyle was associated with a 10%increase in T2D incidence risk(HR=1.1,95%CI:1.1-1.2).Conclusion The risk of T2D in adult residents increases with the cumulative number of unhealthy lifestyles.Adult residents with abnormal WC or BMI,or have three or more unhealthy lifestyles accumulated,will increase the risk of new-onset T2D.
