Managing atopic dermatitis through the perspectives of"clear-turbid interference"and the"gut-skin axis"
10.3969/j.issn.1006-2157.2025.10.010
- VernacularTitle:从"清浊相干"与"肠-皮轴"辨治特应性皮炎
- Author:
Shengxuan ZHAO
1
;
Yang TANG
1
;
Rongxin LI
1
;
Wantong CUI
1
;
Fengjie ZHENG
1
Author Information
1. 北京中医药大学中医学院 北京 100029
- Publication Type:Journal Article
- Keywords:
atopic dermatitis;
gut-skin axis;
clear-turbid interference;
intestinal flora
- From:
Journal of Beijing University of Traditional Chinese Medicine
2025;48(10):1413-1418
- CountryChina
- Language:Chinese
-
Abstract:
Atopic dermatitis is a common chronic,relapsing,inflammatory skin disease;however,its pathogenesis remains unclear.The theory of"clear-turbid interference"originates from the Inner Canon of Yellow Emperor and refers to a pathological condition in which clear yang and turbid yin intermingle,and qi movement becomes disordered.This paper elucidates the theoretical connotation of"clear-turbid interference"and its core mechanism in triggering atopic dermatitis,as well as the role of the"gut-skin axis"in atopic dermatitis development.Internal dampness-turbidity and disharmony between ying and wei constitute the core pathological mechanisms linking clear-turbid interference to atopic dermatitis.Treatment for different stages and syndromes should be guided by syndrome differentiation.For example,for spleen deficiency with a dampness syndrome in subacute or chronic stages,Chushi Weiling Decoction may be used to fortify the spleen,eliminate dampness,lift the clear,and downbear the turbid.For patterns with prominent heat manifestations,such as dampness-heat immersion or heart fire with spleen deficiency,bitter-cold dampness-drying herbs can be added on this basis.For wind-dampness-heat accumulation in the acute stage,Mahuang Lianyao Chixiaodou Decoction can be used to release the exterior,expel pathogens,and harmonize ying and wei.In cases of spleen deficiency with blood dryness or liver-kidney insufficiency during the chronic stage,in addition to nourishing yin to moisten the skin and tonifying the liver-kidney,wind-medicinals should also be employed to open the sweat pores and promote qi movement.These approaches restore the physiological state without clear-turbid interference while regulating intestinal flora,providing new approaches and perspectives for integrating traditional Chinese and Western medicine in treating atopic dermatitis.
