Research Progress on Animal Models of Gastric Ulcer of Spleen-Stomach Deficiency Cold Type
10.12300/j.issn.1674-5817.2025.015
- VernacularTitle:脾胃虚寒型胃溃疡动物模型研究进展
- Author:
Ziqi LIU
1
;
Yunying LI
;
Qin LI
;
Yuanhan LI
;
Fangyan HE
;
Weibo WEN
Author Information
1. 云南中医药大学中药学院,昆明 650500
- Publication Type:Journal Article
- Keywords:
Gastric ulcer;
Spleen-stomach deficiency cold;
Disease-syndrome combination;
Animal model
- From:
Laboratory Animal and Comparative Medicine
2025;45(5):574-585
- CountryChina
- Language:Chinese
-
Abstract:
Gastric ulcer(GU)is one of the common,frequently-occurring and intractable diseases of the digestive system.Spleen-stomach deficiency cold type is the most common and hard-to-cure syndrome pattern of GU,and is both a focus and a challenge in medical research.Therefore,constructing a scientific,reasonable,and clinically practical animal model of GU with spleen-stomach deficiency cold type and formulating objective and effective evaluation criteria are of great significance for in-depth research on the pathogenesis and treatment of GU.In this paper,the methods for constructing GU animal models of spleen-stomach deficiency cold type are comprehensively introduced by systematically reviewing the relevant literature.Firstly,the construction methods of pathological models of GU in Western medicine are introduced,including pyloric ligation method,water immersion-restraint stress method,ethanol-induced method,acetic acid-induced method,etc.This paper expounds the establishment methods for spleen-stomach deficiency cold syndrome type model in traditional Chinese medicine(TCM),including diet disorder method,bitter cold diarrhea method,excessive fatigue method,Qi consumption and Qi impairment method,and overeating sour-flavor method.This paper focuses on the construction methods for disease-syndrome combination GU models of spleen-stomach deficiency cold type,including two-factor modeling method and three-factor modeling method.Meanwhile,the evaluation indices of GU animal models of spleen-stomach deficiency cold type were summarized from various aspects,including animal physical signs(appearance symptoms,animal behavior,and metabolic indices),as well as tissue morphology and molecular biology-related indicators(gastric function,oxidative stress,inflammatory factors,other cytokines,four coagulation parameters,intestinal flora detection),for constructing a comprehensive evaluation system.From the perspective of prescription-based verification,this paper further analyzes the drug composition and pharmacological effects to infer the syndrome type of the treated animal model,so as to verify whether the target animal model is successfully constructed.This review aims to provide a valuable reference for establishing a syndrome-specific GU animal model that closely aligns with clinical reality and embodies the principles of Chinese medicine.This will further advance research on TCM-pattern GU syndromes and deepen the exploration of herbal medicine-based treatments for GU,ultimately promoting the clinical integration and advancement of Chinese medicine in GU therapy.
