Research progress on mechanism of action of selective phosphodiesterase inhibitors in prevention and treatment of inflammatory bowel disease
- VernacularTitle:选择性磷酸二酯酶抑制剂防治炎症性肠病的作用机制研究进展
- Author:
Na GAO
1
;
Yu WANG
1
;
Zhen-hua LIU
1
;
Wei-min YANG
1
;
Chuang XIAO
1
Author Information
- Publication Type:Journal Article
- Keywords: inflammatory bowel disease; phosphodiesterase in-hibitor; cyclic adenosine monophosphate; cyclic guanosine monophosphate; inflammatory response; oxidative stress; molec-ular mechanism
- From: Chinese Pharmacological Bulletin 2025;41(10):1813-1817
- CountryChina
- Language:Chinese
- Abstract: Inflammatory bowel disease(IBD)is a common di-gestive system disease with an increasing morbidity year by year.Its pathological mechanisms have not been fully clarified,and there are currently no ideal or effective curative methods.Phos-phodiesterase(PDE)can regulate intracellular cAMP/cGMP levels to mediate downstream signaling pathways,participating in various pathophysiological processes.In recent years,the po-tential efficacy of PDE inhibitors in the treatment of IBD has gradually attracted attention.This article reviews the pharmaco-logical effects and mechanisms of selective PDE subtype inhibi-tors in the prevention and treatment of IBD,providing references for further research of IBD therapeutic drugs.
