Application of hallucinogens in post-traumatic stress disorder and the related neurobiological mechanisms
- VernacularTitle:致幻剂在创伤后应激障碍中的应用及相关神经生物学机制
- Author:
Yue-ying WANG
1
;
Yi SUN
;
Jing-yu YANG
;
Rui-bin SU
Author Information
- Publication Type:Journal Article
- Keywords: hallucinogens; post-traumatic stress disorder; re-ceptors; neuroplasticity; brain networks; immune regulation
- From: Chinese Pharmacological Bulletin 2025;41(10):1807-1812
- CountryChina
- Language:Chinese
- Abstract: Excessive stress has a significant impact on an indi-vidual's physical and mental health and quality of life.Al-though psychotherapy is commonly used for post-traumatic stress disorder(PTSD),pharmacotherapy plays an important role in the treatment of severe PTSD.At present,there are limited types of approved medications for PTSD,and their efficacy and safety have certain limitations,such as low remission rates,high relapse rates,and increased behavioral risks.Studies have shown that hallucinogens such as psilocybin and ketamine can enhance neuroplasticity,modulate brain network connections,and regulate the immune system by interacting with different re-ceptors,so as to effectively alleviate PTSD symptoms such as anxiety,depression and fear,showing great potential in PTSD treatment.However,these hallucinogens are not yet widely used in clinical practice.This review summarizes the effects and neu-robiological mechanisms of hallucinogens in the treatment of stress-related symptoms,aiming to provide references for the clinical treatment of PTSD.
