Advances in regulation of dysregulated bone remodeling by immune cells within rheumatoid arthritis synovial microenvironment
- VernacularTitle:类风湿关节炎滑膜微环境中免疫细胞对异常骨重塑的调控研究进展
- Author:
Jun-jie HE
1
;
Zhong-liu YAO
;
Ming-yue HU
;
Hong HUANG
;
Xiong CAI
Author Information
- Publication Type:Journal Article
- Keywords: rheumatoid arthritis; bone remodeling; osteoblast; osteoclast; immune cells; bone metabolism
- From: Chinese Pharmacological Bulletin 2025;41(10):1801-1807
- CountryChina
- Language:Chinese
- Abstract: Rheumatoid arthritis(RA)is characterized by bidi-rectional bone remodeling imbalance,clinically termed the "high resorption-low formation" paradox,stemming not only from osteoclast hyperactivation but also critically involving pro-found suppression of osteoblast differentiation and function.No-tably,this suppression cannot be fully attributed to osteoclast hyperactivity;synovium-resident immune cells exert a pivotal regulatory influence through distinct mechanisms.This review systematically examines how synovial immune cells orchestrate bone remodeling in RA through both paracrine cytokine networks and direct cell-cell communication with bone lineage cells,thereby perturbing physiological homeostasis and driving patho-logical progression.These mechanistic revelations yield innova-tive perspectives on RA pathogenesis,positioning immune-medi-ated osteoimmune dysregulation as a promising therapeutic fron-tier for targeted intervention.
