Advances in porcine reproductive and respiratory syndrome virus proteins regulating host innate immunity
- VernacularTitle:猪繁殖与呼吸综合征病毒蛋白调控宿主先天免疫的研究进展
- Author:
Min ZHOU
1
;
Deyuan TANG
1
;
Zhiyong ZENG
1
;
Bin WANG
1
;
Wenwen HU
1
;
Yinming MAO
1
;
Piao ZHOU
1
;
Song HE
1
;
Li ZHANG
1
;
Fangxin GAO
1
Author Information
- Publication Type:Journal Article
- Keywords: porcine reproductive and respiratory syndrome virus; viral proteins; innate immunity; immune suppression
- From: Chinese Journal of Veterinary Science 2025;45(7):1543-1552,1586
- CountryChina
- Language:Chinese
- Abstract: Porcine reproductive and respiratory syndrome virus(PRRSV)is the pathogen of porcine reproductive and respiratory syndrome(PRRS),and its infection mainly causes abortion,stillbirth in sows and piglet respiratory infections,which are widely prevalent in the world and seriously jeopardize the development of the world's animal husbandry industry.PRRSV infection of the host is capable of inducing significant immunosuppression,and in recent years,the study of the mecha-nism of PRRSV immunosuppression has become a hot topic,with studies showing that numerous PRRSV proteins are involved in the regulation of host innate immunity and elucidating the mecha-nism by which PRRSV proteins modulate host innate immunity.In this paper,we reviewed the progress of research on the interaction mechanism between PRRSV proteins and host innate im-munity to provide a theoretical basis for a comprehensive understanding of the pathogenesis of PRRSV and the prevention and control of PRRS.
