Non-genetic Heterogeneity and Drug Resistance in Cholangiocarcinoma
10.3870/j.issn.1672-0741.25.04.004
- VernacularTitle:胆管癌中的非遗传异质性与耐药
- Author:
Lei YANG
1
;
Jianming WANG
Author Information
1. 武汉科技大学附属天佑医院普通外科,武汉 430064
- Publication Type:Journal Article
- Keywords:
cholangiocarcinoma;
drug resistance;
non-genetic heterogeneity;
tumor microenvironment
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2025;54(5):738-742
- CountryChina
- Language:Chinese
-
Abstract:
Cholangiocarcinoma(CCA)is a highly malignant digestive system tumor with strong invasiveness and difficulty in treatment.Its high drug resistance,difficulty in early diagnosis,and rapid progression of invasion and metastasis pose signifi-cant challenges to clinical treatment.Research has shown that the development of resistance in CCA is one of the key factors in-fluencing treatment outcomes,with non-genetic factors playing a crucial role in the resistance process.This article summarizes the non-genetic factors contributing to resistance in CCA,and discusses the roles of epigenetic heterogeneity,epigenetic plastici-ty,and the tumor microenvironment in mediating resistance in CCA.The goal is to provide new theoretical insights for overco-ming treatment resistance in CCA.
