Research Progress on Distress and Emotional Disorders in Cancer
10.3870/j.issn.1672-0741.24.12.032
- VernacularTitle:消极压力与情绪障碍在肿瘤中作用的研究进展
- Author:
Danzeng HE
1
;
Chuanqing WU
1
Author Information
1. 华中科技大学同济医学院附属协和医院胃肠外科,武汉 430022
- Publication Type:Journal Article
- Keywords:
tumor;
stress;
anxiety;
depression
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2025;54(5):734-737
- CountryChina
- Language:Chinese
-
Abstract:
Previous research emphasized negative stress and mood disorders impacting cancer patients' quality of life.Growing evidence indicates these psychological factors directly influence cancer prognosis,with molecular mechanisms being explored and validated in animal models.Acting as cancer risk factors,psychological stress and mood disorders modulate the tumor immune microenvironment via the hypothalamic-pituitary-adrenal axis or sympathetic nervous system,suppressing anti-tumor immunity.Conversely,the tumor acts as a stressor,inducing mood disorders that further impair patient outcomes and quality of life,creating a vicious cycle.Investigating the mechanisms of this bidirectional stress-tumor interplay and identifying therapeutic targets to disrupt it are crucial for improving cancer patient prognosis and well-being.
