Association Between Lipoprotein(a)and the Incidence and Severity of Coronary Artery Disease among the Young Population
10.3870/j.issn.1672-0741.25.01.010
- VernacularTitle:青年人群中脂蛋白(a)与冠心病及病变程度的关联分析
- Author:
Jie LI
1
;
Hu DING
1
;
Yan WANG
1
Author Information
1. 华中科技大学同济医学院附属同济医院心血管内科,武汉 430030
- Publication Type:Journal Article
- Keywords:
coronary artery disease;
lipoprotein(a);
the young population;
Gensini score
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2025;54(5):686-693
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between lipoprotein(a)[Lp(a)]and the incidence and severity of coro-nary artery disease(CAD)among the young population.Methods A total of 2202 patients,aged 45 years or younger,who under-went coronary angiography,were included in this study.Clinical data were collected from a large data platform in the hospi-tal.Univariate and multivariate logistic regression analyses were used to evaluate the association between Lp(a)and CAD,mul-tivessel CAD,and high Gensini scores.Subgroup analyses were conducted to evaluate the heterogeneity of the association be-tween Lp(a)and CAD,multivessel CAD,and high Gensini scores under different clinical risk factors.Results In the overall population,after adjusting for confounding factors,when Lp(a)was treated as a continuous variable,Lp(a)levels were signifi-cantly positively associated with the incidence of CAD[OR(95％CI):1.21(1.10-1.33),P＜0.01],multivessel CAD[OR(95％CI):1.41(1.26-1.58),P＜0.01],and high Gensini scores[OR(95％CI):1.22(1.10-1.36),P＜0.01].When Lp(a)was treated as a categorical variable,with the first quartile(Q1)as the reference,the fourth quartile(Q4)of Lp(a)was significantly associated with the incidence of CAD[OR(95％CI):1.56(1.19-2.03),P＜0.01],multivessel CAD[OR(95％CI):2.32(1.71-3.14),P＜0.01],and high Gensini scores[OR(95％CI):1.62(1.20-2.18),P＜0.01].Subgroup analyses showed the inter-action between Lp(a)and low-density lipoprotein cholesterol(P for interaction＜0.05),as well as Lp(a)and high-density lipo-protein cholesterol(P for interaction＜0.01)in multivessel CAD.Conclusion In the overall young population,Lp(a)is signifi-cantly associated with the incidence and severity of CAD,independent of traditional risk factors and conventional lipids,emphasi-zing the importance of early detection and early intervention of Lp(a).
