Effect of Pre-pregnancy Overweight/Obesity Complicated with Gestational Diabetes Mellitus on BMIZ Growth Trajectories in the First Year of Life
10.3870/j.issn.1672-0741.25.03.026
- VernacularTitle:孕前超重肥胖合并妊娠糖尿病对子代0～1岁BMIZ生长轨迹的影响
- Author:
Hengying CHEN
1
;
Baohua ZHENG
;
Yanfen JIANG
Author Information
1. 华中科技大学同济医学院公共卫生学院儿少卫生与妇幼保健系,武汉 430030
- Publication Type:Journal Article
- Keywords:
pre-pregnancy overweight/obesity;
gestational diabetes mellitus;
body mass index z score;
growth traj-ectory
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2025;54(5):679-685
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the independent and combined impact of pre-pregnancy overweight or obesity(OWOB)and gestational diabetes mellitus(GDM)on infant body mass index-for-age z score(BMIZ)growth trajectories during the first year of life.Methods A retrospective cohort study was conducted using data from Zhuhai Center for Maternal and Child Health Care between June 2022 and October 2024.A total of 4481 mother-infant pairs meeting the inclusion criteria were enrolled.Pre-pregnancy body mass index(BMI),second-trimester oral glucose tolerance test(OGTT)results,and longitudinal growth data of offspring(including weight and length at birth and at 1,3,6,9,and 12 months of age)were collected.A latent class growth mod-el was used to identify distinct BMIZ trajectories,and multinomial logistic regression was applied to examine the independent and combined effects of maternal OWOB and GDM on offspring BMIZ trajectories.Results Three distinct BMIZ trajectories were identified:appropriate-stable,rapid growth,and catch-up growth.Compared with offspring of mothers with normal pre-pregnancy BMI and without GDM,those born to mothers with both pre-pregnancy OWOB and GDM had a significantly higher risk of following a catch-up growth trajectory(OR=1.74,95％CI:1.13-2.68)or a rapid growth trajectory(OR=1.33,95％CI:1.03-1.71).However,no significant associations were observed in the offspring of mothers with OWOB alone or GDM a-lone(all P＞0.05).Additionally,when comparing offspring of mothers with both OWOB and GDM to those offspring of moth-ers with OWOB alone or GDM alone,no significant differences in BMIZ trajectory risk were found(all P＞0.05).Conclusion Pre-pregnancy OWOB combined with GDM,but not pre-pregnancy OWOB or GDM alone,increases risk of rapid growth and catch-up BMIZ trajectory of offspring.These findings highlight the importance of optimizing maternal pre-pregnancy weight and maintaining appropriate glycemic control during pregnancy promotes healthier infant growth patterns.
