Research Progress on the Prevention and Treatment of Ulcerative Colitis by Traditional Chinese Medicine Based on the MAPK Signaling Pathway
- VernacularTitle:基于MAPK信号通路探究中药防治溃疡性结肠炎研究进展
- Author:
Linguo CAO
1
;
Yanyan WANG
;
Kexin DENG
;
Jiaqing LIU
;
Zuowu XI
;
Zongyue GAO
;
Kai WANG
Author Information
- Publication Type:Journal Article
- Keywords: Ulcerative colitis; MAPK signaling pathway; Traditional Chinese medicine; Mechanism; Research progress
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2025;27(9):2624-2635
- CountryChina
- Language:Chinese
- Abstract: Ulcerative colitis(UC)is a common chronic non-specific intestinal inflammatory disease clinically.Its pathogenesis is complex,prolonged the disease course,and it is frequent clinical recurrence.In recent years,the incidence of UC has shown an upward trend and tends to younger onset,which seriously affects the quality of life of patients and increases the social medical burden.Mitogen-activated protein kinase(MAPK)plays an important role in the occurrence and development of UC,participating in inflammatory response,oxidative stress,autophagy,apoptosis,pyroptosis,and intestinal barrier.MAPK may be a new target for the treatment of UC.Traditional Chinese medicine has a long history and remarkable curative effect in treating UC,with the advantages of multiple pathways,multiple targets,and multiple components.In recent years,many studies have shown that single Chinese herbal medicines and compound prescriptions can mediate MAPK signaling pathway to inhibit inflammatory response and oxidative stress,regulate autophagy,inhibit apoptosis and pyroptosis,repair the intestinal barrier,and treat UC in many aspects.This article reviews the MAPK signaling pathway,the mechanism by which the MAPK signaling pathway regulates UC,and the research progress of traditional Chinese medicine in treating UC based on the MAPK signaling pathway,hoping to provide theoretical support for the treatment of UC by traditional Chinese medicine and new ideas and references for the research of related new drugs.
