Effect and mechanism of Chu's Antai formula combined with dydrogesterone for the treatment of unexplained recurrent abortion with kidney deficiency pattern
10.12007/j.issn.0258-4646.2025.10.008
- VernacularTitle:褚氏安胎方联合地屈孕酮治疗肾虚型不明原因复发性流产的效果及作用机制
- Author:
Hui LI
1
;
Yuxia CHU
1
Author Information
1. 河南省中医院,河南中医药大学第二附属医院生殖医学科,郑州 450002
- Publication Type:Journal Article
- Keywords:
kidney deficiency pattern;
unexplained recurrent abortion;
Chu's Antai formula;
dydrogesterone
- From:
Journal of China Medical University
2025;54(10):907-913
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the efficacy of Chu's Antai formula combined with dydrogesterone for the treatment of unexplained recurrent abortion(URA)with kidney deficiency pattern and its possible mechanism of action.Methods A total of 68 patients with URA with kidney deficiency pattern admitted to our hospital between April 2023 and October 2023 were selected and randomly divided into the study and conventional groups,with 34 patients in each group.The conventional group received luteal support therapy with oral dydro-gesterone(10 mg twice daily),whereas the study group received an additional Chu's Antai formula(one dose/d,divided into morning and evening doses)based on conventional treatment.Both groups were treated until 14 weeks of gestation.The t test,x2 test,and Fisher's exact test were performed to compare the traditional Chinese medicine(TCM)symptom scores,serum sex hormone levels(estradiol[E2],progesterone[P],and human chorionic gonadotropin[HCG]),inflammatory cytokine levels,clinical efficacy,adverse reactions,and preg-nancy outcomes between the two groups before and after treatment.Results After treatment,the primary symptom,secondary symptom,and total scores were lower in the study group than in the conventional group(P＜0.05).The total effective treatment rate was higher in the study group than in the conventional group(P＜0.05).After treatment,serum E2,P,and HCG levels in both groups were higher than those before treatment(P＜0.05),and the study group showed higher sex hormone levels than the conventional group(P＜0.05).After treatment,interleukin(IL)-2,tumor necrosis factor α(TN F-α),interferon γ(INF-γ),and IL-17 serum levels in both groups were lower than those before treatment(P＜0.05);IL-2,TNF-α,INF-γ,and IL-17 levels were significantly lower in the study group than in the con-ventional group(P＜0.05).After treatment,IL-4,IL-6,IL-10,and transforming growth factor β1(TGF-β1)serum levels in both groups were higher than those before treatment(P＜0.05),and IL-4,IL-6,IL-10,and TGF-β1 levels in the study group were significantly higher than those in the conventional group(P＜0.05).No significant adverse reactions were observed in any group.Notably,the pregnancy suc-cess rate was higher in the study group than in the conventional group(73.53％vs.47.06％,P＜0.05).Conclusion Chu's Antai formula combined with dydrogesterone improved TCM symptoms,hormone levels,and pregnancy outcomes in patients with URA with kidney defi-ciency pattern,thereby enhancing clinical efficacy.The underlying mechanism may involve the restoration of the balance between Th1/Th2 and Th17/Treg cells.
