Efficacy and safety of 0.02％ atropine eye drops in treating nearwork-induced transient myopia in adolescents
10.12007/j.issn.0258-4646.2025.10.015
- VernacularTitle:0.02％阿托品滴眼液治疗青少年近距离工作引起的暂时性近视的有效性和安全性
- Author:
Lei GUO
1
;
Jun TAO
;
Zhiyuan WEI
;
Hongbo YU
;
Wenzhuo CAI
;
Ziqi GUO
;
Rui HUA
Author Information
1. 中国医科大学附属第一医院眼科,沈阳 110001;兴齐眼科医院眼科,沈阳 110004
- Publication Type:Journal Article
- Keywords:
0.02％ atropine eye drop;
nearwork-induced transient myopia;
randomized controlled trial;
efficacy;
safety
- From:
Journal of China Medical University
2025;54(10):946-950
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the efficacy and safety of 0.02％atropine eye drops for the treatment of nearwork-induced transient myopia(NITM)in adolescents.Methods A total of 131 adolescents with NITM were randomly divided into experimental(receiving 0.02％atropine eye drops)and control(receiving placebo)groups.Changes in the initial NITM values before medication and at 14 and 30 days after medication were observed.Alterations in intraocular pressure and accommodation amplitude were monitored,and the occurrence of complications,such as photophobia and near vision impairment,were recorded.Results The baseline NITM did not differ significantly between the two groups.On day 14 and day 30,the NITM values in the experimental group were significantly reduced compared to the baseline,with differences of 0.31 D±0.20 D and 0.30 D±0.16 D,which were significantly greater than those in the control group(0.21 D±0.98 D and 0.20 D±0.18 D,P＜0.001).The efficacy rate of NITM treatment in the experimental group was 84.4％,which was sig-nificantly higher than that in the control group(29.9％).After 30 days of treatment,no severe systemic or ocular adverse reactions were observed in the experimental group.Mild photophobia was the main adverse reaction.Conclusion 0.02％atropine eye drops can effec-tively reduce the initial NITM value in adolescents within a month of its use,with no severe complications and good tolerance.A clinical trial of atropine eye drops at different concentrations to reduce NITM over a longer period is warranted.
