A Multicenter Controlled Study on the Evaluation of Aseptic Compounding Operations Ability of PIVAS Personnel by Media Fill Test
10.3870/j.issn.1004-0781.2025.11.021
- VernacularTitle:培养基灌装试验评价医院静脉用药调配中心人员无菌调配操作能力的多中心对照研究
- Author:
Fan ZHANG
1
;
Yuanyuan MA
;
Xinyi WANG
;
Donghui LAO
;
Yongguang SHANG
;
Xiaohong ZHU
;
Yuzhen ZOU
;
Lei JIAO
;
Weiyan TANG
;
Jianzhong ZHANG
;
Wei YANG
;
Mei DONG
;
Cuilian ZHANG
;
Lulu SUN
;
Bin ZHAO
Author Information
1. 中国医学科学院北京协和医学院北京协和医院药剂科,北京 100730
- Publication Type:Journal Article
- Keywords:
Media fill test;
Pharmacy intravenous admixture services;
Sterile operation;
Multicenter study
- From:
Herald of Medicine
2025;44(11):1848-1853
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the practical application of the Media Fill Test(MFT)in assessing aseptic compounding competency of personnel in Pharmacy Intravenous Admixture Services(PIVAS).Methods A multicenter controlled study was conducted across six tertiary hospitals(center ①-⑥)in China.Participants were divided into an inexperienced group(Group A,n=118)and an experienced group(Group B,n=118),each performing five MFT operations.Positive controls validated medium efficacy.Contamination rates and pass rates were analyzed using chi-square and Fisher's exact tests.Results Valid samples included 584 for Group A and 588 for Group B.The sample pass rate was 66.78%(390/584)in Group A and 91.67%(539/588)in Group B,while personnel pass rates were 46.15%(54/117)and 80.51%(95/118),respectively,with significant intergroup differences(both P<0.01).All centers except Center ⑥ showed significantly higher pass rates in Group B(all P<0.05).Conclusion MFT effectively differentiates technical proficiency levels and is suitable for training evaluation of novice PIVAS staff.
