Comprehensive Clinical Evaluation of Different Preparations of Amphotericin B Based on A Quick Guideline for Drug Evaluation and Selection in Chinese Medical Institutions(the Second Edition)
10.3870/j.issn.1004-0781.2025.11.019
- VernacularTitle:基于《中国医疗机构药品评价与遴选快速指南(第二版)》的两性霉素B不同制剂临床综合评价
- Author:
Chaoli CHEN
1
;
Ran FU
;
Donghan WANG
;
Luyao CHANG
;
Yang SONG
;
Jing YU
;
Chunhua ZHOU
Author Information
1. 河北医科大学第一医院临床药学部,石家庄 050000
- Publication Type:Journal Article
- Keywords:
Amphotericin B;
Amphotericin B Deoxycholate;
Liposomal Amphotericin B;
Amphotericin B colloidal dispersion;
Selection of drug;
Comprehensive evaluation
- From:
Herald of Medicine
2025;44(11):1835-1842
- CountryChina
- Language:Chinese
-
Abstract:
Objective To conduct a comprehensive evaluation of Amphotericin B Deoxycholate(AmB-D)for injection,Liposomal Amphotericin B(L-AmB)for injection,and Amphotericin B Colloidal Dispersion(ABCD)for injection,and to provide a reference for the selection and rational use of drugs in medical institutions.Methods Based on the quantitative evaluation and selection record form in the A Quick Guideline for Drug Evaluation and Selection in Chinese Medical Institutions(the Second Edition),evidence was collected to conduct a comprehensive assessment of the included drugs.Results Comprehensively considering the pharmacological properties,efficacy,safety,economy,and other attributes of different preparations of amphotericin B,the quantitative scoring results were ranked from high to low,with ABCD(CSPC Ouyi Pharmaceutical Co.,Ltd.)scoring 79.10 points,L-AmB(Gilead Sciences)scoring 78.30 points,and L-AmB(Shanghai Shangyao Xinya Pharmaceutical Co.,Ltd.)scoring 72.01 points.AmB-D(Shanghai Shanghai Pharmaceutical Xinya Pharmaceutical Co.,Ltd)scored 63.20 points,and AmB-D(North China Pharmaceutical Co.,Ltd.)scored 59.78 points.Conclusion Both L-AmB and ABCD have better clinical efficacy and higher safety in the treatment of invasive fungal infections,and ABCD has a better price advantage than L-AmB.Based on A Quick Guideline for Drug Evaluation and Selection in Chinese Medical Institutions(the Second Edition),the evaluation results of different preparations of amphotericin B can provide a reference for the selection and rational use of amphotericin B in medical institutions.
