Research progress on the effect of obesity-induced changes in sperm epigenetic factors on offspring health
10.3760/cma.j.cn101441-20200704-00377
- VernacularTitle:肥胖导致精子表观因子变化影响子代健康的研究进展
- Author:
Huan WANG
1
;
Qingling YANG
1
;
Yingpu SUN
1
Author Information
1. 郑州大学第一附属医院生殖与遗传专科医院，郑州 450052
- Publication Type:Journal Article
- Keywords:
Obesity;
Spermatozoa;
Epigenetics;
Offspring
- From:
Chinese Journal of Reproduction and Contraception
2022;42(2):204-208
- CountryChina
- Language:Chinese
-
Abstract:
Obesity is a complex, multifactorial disease. More than 1.9 billion adults worldwide are obese, with men accounting for about half. With the number of obese men increasing, the proportion of sperm quality decline and male infertility gradually rise. Recent studies have shown that obesity can affect spermatogenesis through epigenetic changes. Epigenetics is the study of changes in gene expression without changing nucleotide sequence, which mainly includes three aspects: DNA methylation, histone modification and non-coding RNA (ncRNA). Animal model studies have shown that obesity is directly related to epigenetic changes in sperm, somatic cells of offspring and germ cells. Epigenetic changes play a crucial role in male infertility by regulating the formation and development of germ cells. Epigenetic changes can lead to sperm abnormalities and sperm function abnormalities. Obesity alters epigenetic factors that can not only alter sperm function, but also affect offspring, for example paternal obesity can affect the metabolism and reproductive phenotype of offspring through sperm epigenetic reprogramming, and appropriate intervention measures can improve the epigenetic genes of sperm and offspring in obese people. This paper will review the epigenetic changes of sperm caused by obesity, the influence on offspring and the influence of intervention measures on sperm epigenetic changes.
