Effects of G-CDOP Regimen on Liver Function in the Treatment of Follicular Lymphoma in the Real World
10.3870/j.issn.1004-0781.2025.11.018
- VernacularTitle:真实世界G-CDOP方案治疗滤泡性淋巴瘤对肝功能的影响
- Author:
Xiao ZHANG
1
;
Fan XIA
;
Cheng XIE
;
Changju QU
;
Yiduo DING
Author Information
1. 苏州大学附属第一医院血液内科,苏州 215006
- Publication Type:Journal Article
- Keywords:
Follicular lymphoma;
G-CDOP regimen;
Obinutuzumab;
Liver function;
Real world
- From:
Herald of Medicine
2025;44(11):1830-1834
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the occurrence of liver function abnormalities in patients with follicular lymphoma(FL)treated with the G-CDOP regimen in the real world.Methods Using the hospital information system,a retrospective collection of clinical data was conducted on inpatients diagnosed with FL and treated with at least four courses of the G-CDOP regimen in the Department of Hematology,the First Affiliated Hospital of Soochow University from September 2021 to August 2023.The analysis focused on the incidence,severity,and types of liver function abnormalities,as well as the timing of these occurrences in relation to medication use and other relevant clinical characteristics.Results The study encompassed a total of 55 patients with FL,out of which 30 patients encountered liver function abnormalities during the G-CDOP regimen treatment,yielding an incidence rate of 54.5%.There were 23 cases(41.8%)of grade 1,3 cases(5.5%)of grade 2,and 4 cases(7.3%)of grade 3 liver function abnormalities.Among them,12 cases(21.8%)were hepatocellular injury type,while the cholestasis type was observed in 4 cases(7.3%),and the mixed type was found in 14 cases(25.5%).Liver function abnormalities appeared in 21 patients(38.2%)during the first cycle of the G-CDOP regimen treatment,5 patients(9.1%)in the second cycle,and 1 patient(1.8%),2 patients(3.6%),and 1 patient(1.8%)in the third,fourth,and fifth cycles.Conclusion The G-CDOP regimen has the potential to impact liver function indicators in FL patients,but most are mild and reversible.However,there are also cases of severe liver injury that need to attract clinical attention.
