Effects of controlled ovarian hyperstimulation on thyroid function in infertile subclinical hypothyroidism women
10.3760/cma.j.cn101441-20210125-00037
- VernacularTitle:控制性超促排卵技术对亚临床甲状腺功能减退患者甲状腺功能的影响
- Author:
Yunying CAI
1
;
Lanping ZHONG
;
Ze WU
;
Heng SU
Author Information
1. 云南省第一人民医院 昆明理工大学附属医院内分泌代谢科，昆明 650032
- Publication Type:Journal Article
- Keywords:
Controlled ovarian hyperstimulation;
Subclinical hypothyroidism;
Thyroid function
- From:
Chinese Journal of Reproduction and Contraception
2022;42(7):675-681
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the impact of controlled ovarian hyperstimulation(COH) on thyroid function in infertile subclinical hypothyroidism (SCH) women treated with levothyroxine (LT4).Methods:A cohort study included LT4 treated infertile SCH patients undergoing in vitro fertilization/intracytoplasmic sperm injection and embryo transfer (IVF/ICSI-ET) from January 2015 to March 2017 in the Reproductive Center of the First People's Hospital of Yunnan Province were retrospectively analyzed. Finally, the paired thyroid hormone data of 124 patients before and after COH were included for statistical analysis. According to baseline thyroid stimulating hormone (TSH) level, women were divided into 0.2 mU/L≤TSH≤2.5 mU/L group ( n=88) and 2.5 mU/L4.2 mU/L, 77.8% (28/36) vs. 40.9% (36/88), P<0.001]. At the 14th day after ET, the TSH level in the clinical pregnancy group was significantly higher than that in the non-pregnancy group [6.09(2.18, 9.09) mU/L vs. 1.84(0.62, 4.45) mU/L, P=0.002]. The increment of TSH level was more significant in ATA positive group compared with ATA negative group after COH ( P=0.013). Conclusion:COH had a significant effect on serum TSH in LT4 treated infertile SCH women. The possible influence factors may include the baseline TSH level, status of ATA and pregnancy.
