Tumor microenvironment metabolism:an ongoing therapeutic target
10.3969/j.issn.1672-8467.2025.05.014
- VernacularTitle:肿瘤微环境代谢:一个持续的治疗靶点
- Author:
Ji-tong ZHAO
1
;
Mei-qi FENG
1
;
Xiao-yan ZHANG
1
Author Information
1. 复旦大学生物医学研究院 上海 200032;上海市公共卫生临床中心 上海 201540
- Publication Type:Journal Article
- Keywords:
tumor microenvironment(TME);
metabolism;
immunotherapy;
subacidity;
hypoxia
- From:
Fudan University Journal of Medical Sciences
2025;52(5):724-732
- CountryChina
- Language:Chinese
-
Abstract:
Tumor microenvironment(TME)is the foundation for tumor survival,which is composed of various types of cells,tumor blood vessels,secretory factors,and extracellular matrix(ECM)within the tumor.The unique regulatory mechanism triggered by the vigorous metabolic demand of tumor plays an important role in its tumorigenesis,metastasis,invasion,and treatment resistance.A deeper understanding of the metabolic transformation and tumor-immune cell interactions in the TME will enable the development of therapeutic technologies that precisely target TME metabolism,facilitate the development of combination treatment strategies,and improve the clinical response rate of existing immunotherapies.This paper reviews the composition,metabolism and regulatory mechanisms of TME,summarizes the research progress of immunotherapy strategies targeting the physiological characteristics of TME,and discusses the prospects for clinical application of precision immunotherapy strategies targeting TME,which are expected to enhance immunotherapy drugs response and infiltration degree.
