Relationship between Serum STAT1,STAT3 and Prognosis in Patients with Severe Pneumonia Complicated with Septic Shock
10.11969/j.issn.1673-548X.2025.09.019
- VernacularTitle:重症肺炎合并感染性休克患者血清STAT1、STAT3与预后的关系研究
- Author:
Huimin YUAN
1
;
Lei WANG
1
;
Yanfen DING
1
Author Information
1. 201900 上海交通大学医学院附属第九人民医院急诊科
- Publication Type:Journal Article
- Keywords:
Severe pneumonia;
Septic shock;
Signal transducer and activator of transcription protein 1;
Signal transducer and acti-vator of transcription protein 3;
Prognosis;
Correlation
- From:
Journal of Medical Research
2025;54(9):109-113,168
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum signal transducer and activator of transcription protein(STAT)1,STAT3 levels and prognosis in patients with severe pneumonia(SP)complicated with septic shock(SS).Methods A total of 105 patients with SP complicated with SS(SP+SS group)and 105 healthy physical examination volunteers(control group)admitted to Shang-hai Ninth Poople's Hospital,Shanghal JiaoTong University School of Medicine from January 2021 to October 2023 were selected in a 1:1 ratio.Based on the 28-day prognosis,the patients in the SP+SS group were divided into the survival group and the death group.Serum STAT1 and STAT3 levels were detected by enzyme-linked immunosorbent assay.Multivariate Logistic regression and receiver operating characteristic curve analyses were performed to assess the relationship between serum STAT1,STAT3 levels and prognosis,as well as their predictive value.Results Compared with the control group,the levels of serum STAT1 and STAT3 were significantly higher in the SP+SS group(P＜0.05).The 28-day mortality of SP+SS patients was 47.62％(50/105)after admission.Compared with the survival group,the levels of serum STAT1 and STAT3 were significantly higher in the death group(P＜0.05).Higher sequential organ failure as-sessment scores,increased acute physiology and chronic health evaluation Ⅱ scores,elevated STAT1,and elevated STAT3 were identified as independent risk factors for death in SP+SS patients(P＜0.05).The area under the curve(AUC)for predicting the death of patients with SP+SS by serum STAT1,STAT3 levels alone,and their combined prediction were 0.778,0.787 and 0.880,respectively.The De-Long test showed that the AUC for the combined prediction was significantly higher than that of STAT1 or STAT3 levels alone(P＜0.05).Conclusion Elevated serum STAT1 and STAT3 levels are associated with increased mortality in SP+SS patients,and their combined de-tection has high predictive value for prognosis.
