Relationship between Serum Cystatin C,KIM-1 and Acute Kidney Injury and Prognosis after Laparoscopic Nephron Sparing Surgery in Patients with Renal Cell Carcinoma
10.11969/j.issn.1673-548X.2025.09.018
- VernacularTitle:血清CysC、KIM-1与肾癌患者腹腔镜下保留肾单位肿瘤切除术后急性肾损伤及预后的关系
- Author:
Qingjun GUAN
1
;
Nan ZHANG
1
;
Kun CHEN
1
Author Information
1. 450003 河南中医药大学第五临床医学院(郑州人民医院)泌尿外科
- Publication Type:Journal Article
- Keywords:
CysC;
KIM-1;
Laparoscopic nephron sparing surgery;
Acute kidney injury;
Prognosis
- From:
Journal of Medical Research
2025;54(9):103-108
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between serum CysC,KIM-1 and acute kidney injury(AKI)and prognosis in patients with renal cell carcinoma after laparoscopic nephron sparing surgery(LNSS).Methods A total of 62 patients with renal cell carcinoma who underwent LNSS in our hospital were collected.Serum CysC and KIM-1 levels were detected by immunoturbidimetry and enzyme-linked immunosorbent assay,respectively.According to whether AKI occurred and recurrence after surgery,the patients were divided into the non-AKI group(n=34)and AKI group(n=28),as well as the good prognosis group(n=45)and poor prognosis group(n=17).Univariate and multivariate Logistic regression were used to analyze the influencing factors of AKI and poor prognosis.The predictive value of CysC and KIM-1 for AKI and poor prognosis was analyzed by the receiver operating characteristic(ROC)curve.Results There were significant differences in gender,hypertension,diabetes,operation time,glomerular filtration rate(GFR),renal artery occlusion time and KIM-1 level between the non-AKI group and AKI group(P＜0.05).There were significant differences in tumor diameter,grade,lymph node metastasis,CysC and KIM-1 level between the good prognosis group and poor prognosis group(P＜0.05).Multivariate Logistic regression showed that gender,diabetes,GFR,renal artery occlusion time and KIM-1 level were independ-ent risk factors for AKI while GFR was an independent protective factor for AKI(P＜0.05);tumor diameter,serum CysC and KIM-1 level were independent risk factors for poor prognosis(P＜0.05).ROC curve analysis showed that the area under the curve(AUC)of KIM-1 for predicting AKI was 0.687;The AUC of CysC and KIM-1 for predicting poor prognosis were 0.829 and 0.871,respectively.Conclusion Serum KIM-1 is an independent risk factor for AKI after LNSS in patients with renal cell carcinoma,and serum CysC and KIM-1 are independent risk factors for poor prognosis.
