Association between Atherosclerosis in Type 2 Diabetes Mellitus and Bone Mineral Density and Fracture Risk
10.11969/j.issn.1673-548X.2025.09.015
- VernacularTitle:2型糖尿病患者动脉粥样硬化与骨密度及骨折风险的关系研究
- Author:
Peiqi FU
1
;
Qiuyue REN
1
;
Jinghui HAN
1
Author Information
1. 450000 郑州,河南中医药大学第一附属医院内分泌科
- Publication Type:Journal Article
- Keywords:
Type 2diabetes;
Atherosclerosis;
Bone mineral density;
Risk of fracture
- From:
Journal of Medical Research
2025;54(9):86-90,4
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between atherosclerosis(AS)and bone mineral density(BMD)as well as frac-ture risk in patients with type 2diabetes mellitus(T2DM).Methods A total of 380 T2DM patients aged 50-80 years were included and divided into AS group and non-AS group based on carotid intima-media thickness.Clinical indicators were compared between the two groups,and the relationship between AS and BMD as well as fracture risk was analyzed.Results The AS group had higher age,diabetes duration,incidence of osteopenia,10-year probability of major osteoporotic fracture(PMOF),and 10-year probability of hip fracture(PHF),while having lower femoral neck BMD than the non-AS group.In male T2DM patients,PMOF and PHF were positively correla-ted with age,diabetes duration,and AS lesions,and negatively correlated with total cholesterol,triglycerides,low-density lipoprotein,25-hydroxyvitamin D,type Ⅰ procollagen amino-terminal peptide,and BMD.In female T2DM patients,PMOF and PHF were posi-tively correlated with menopause duration,fasting insulin,and AS lesions,and negatively correlated with blood phosphorus and BMD.Regression analysis showed that osteopenia was an independent risk factor for AS lesions in male T2DM patients,AS lesions were an inde-pendent risk factor for BMD levels,and body mass index was an independent protective factor for BMD levels.In female T2DM patients,age,fasting insulin,and high-density lipoprotein were independent risk factors for BMD levels,and parathyroid hormone was an inde-pendent protective factor for BMD levels.Conclusion When T2DM patients have AS lesions,the incidence of low bone mass and osteo-porosis is higher,with decreased femoral neck BMD and increased PMOF and PHF.In male subjects,low bone mass and osteoporosis are independent risk factors for AS lesions,and AS lesions are also independent risk factors for BMD levels.
