Mechanism and Research Progress of Pentraxin 3 in Glioblastoma Multiforme
10.3870/j.issn.1004-0781.2025.08.014
- VernacularTitle:正五聚蛋白3在神经胶质母细胞瘤中作用机制及研究进展
- Author:
Xiaoxue LI
1
;
Wan LI
;
Wanxin CAO
;
Fang XU
;
Hong YANG
;
Xiangyin CHI
;
Guanhua DU
;
Mingyu XIA
;
Jinhua WANG
Author Information
1. 沈阳药科大学生命科学与生物制药学院,沈阳 110000;中国医学科学院·北京协和医学院药物研究所,脑血管病新药发现及晶型研究北京市重点实验室,北京 100050
- Publication Type:Journal Article
- Keywords:
Pentraxin 3;
Glioblastoma multiforme;
Mechanism;
Drug target;
Expression regulation;
Pentamer protein superfamily
- From:
Herald of Medicine
2025;44(8):1281-1289
- CountryChina
- Language:Chinese
-
Abstract:
Glioblastoma multiforme(GBM)is a grade 4 glioma with the highest malignancy and invasiveness in the central nervous system,accounting for approximately 30％of all tumors in the central nervous system.Due to the unclear pathogenesis of GBM,there is currently no specific target for the treatment of GBM.Temozolomide(TMZ)is the only first-line chemotherapeutic drug for the treatment of GBM,but suffers from a low drug response rate and high susceptibility to drug resistance.Therefore,the development of new targets and novel GBM therapeutic agents is an urgent clinical problem.Pentraxin 3(PTX3),a member of the pentameric protein superfamily,has been shown to have a promotive effect on a variety of tumors.Increasing evidences showed that PTX3 played a crucial role in the progression of GBM.PTX3 can promote the proliferation,migration and invasion ability of GBM cells,increase the angiogenesis ability in the GBM microenvironment and malignant progression of GBM.In the article,the structure,physiological function,expression regulation,role and mechanism of PTX3 in GBM were mainly reviewed,with a view to provide guidance for PTX3 as a potential drug target for the treatment of GBM.
