Research progress on the application of kaempferol in ophthalmology
10.13389/j.cnki.rao.2025.0158
- VernacularTitle:山奈酚在眼科疾病治疗中的作用研究进展
- Author:
Jingyi YANG
1
;
Gaolei WANG
;
Bin GUO
;
Hongsheng BI
Author Information
1. 250014 山东省济南市,山东中医药大学
- Publication Type:Journal Article
- Keywords:
kaempferol;
ophthalmic diseases;
antioxidant;
anti-inflammatory;
immunomodulation
- From:
Recent Advances in Ophthalmology
2025;45(11):919-924
- CountryChina
- Language:Chinese
-
Abstract:
Kaempferol(KAE),as a natural flavonoid compound,possesses multiple biological activities including po-tent anti-inflammatory,antioxidant,and immunomodulatory effects,as well as anti-cancer properties.It has demonstrated good therapeutic effects in the intervention and treatment of various ocular diseases such as fungal keratitis,corneal trans-plantation rejection,age-related macular degeneration,and diabetic retinopathy.Furthermore,the development of novel ocular drug delivery systems-such as KAE-loaded bovine serum albumin porous membranes,KAE eye drops based on poly-vinylpyrrolidone nanocomplexes,gelatin nanoparticles encapsulating KAE,and platelet-derived extracellular vesicles loaded with KAE-has improved the bioavailability of KAE,laying a foundation for expanding its applications.However,there is a lack of systematic and comprehensive reviews on the application of KAE in ophthalmic diseases.Therefore,this article summarizes the research progress,efficacy mechanisms,and novel delivery methods of KAE in ophthalmic diseases,ai-ming to provide new diagnostic and therapeutic strategies for the treatment of related ocular conditions.
