Association between parental characteristics during peri-conceptional period and risk of autism spectrum disorders in children
10.3760/cma.j.cn101441-20201127-00647
- VernacularTitle:父母亲生育年龄等围孕期因素与儿童孤独症谱系障碍的关联性
- Author:
Yanyan MAO
1
;
Hong HU
;
Dongyan CHEN
;
Yasong DU
;
Yuhang FANG
;
Shangming WANG
;
Min LI
;
Weijin ZHOU
Author Information
1. 上海市生物医药技术研究院，国家卫生健康委员会计划生育药具重点实验室，上海 200237
- Publication Type:Journal Article
- Keywords:
Risk factor;
Paternal age;
Maternal age;
Autism spectrum disorder
- From:
Chinese Journal of Reproduction and Contraception
2022;42(4):372-378
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To examine the association between parental characteristics and risk of autism spectrum disorder (ASD) in children.Methods:In this case-control study, the cases were defined as children who were diagnosed with ASD and were recruited from June 2018 to February 2019 in Shanghai Mental Center ( n=104). The controls were defined as children who did not have ASD and were recruited in the two community health centers in Jing-an District of Shanghai during the same period ( n=149). All children recruited in this study were 2-6 years old. A multivariate logistic regression model was used to examine the association between parental characteristics and the risk of ASD in offspring, and further to estimate the interaction coefficient. Results:According to multivariate regression analysis, the association between maternal age, previous pregnancy complication and the risk of ASD in children appeared to be not statistically significant. After adjusted, advanced paternal age (≥35 years old)( OR=3.65, 95% CI=1.19-11.15, P=0.023), parental disease before or during pregnancy ( OR=3.34, 95% CI=1.41-7.94, P=0.006) and gender of child (male) ( OR=5.84, 95% CI=2.98-11.44, P<0.001) were associated with increased risk of ASD. The results also showed that the boys whose father was 35 years old or more had a higher risk of ASD than the boys whose fahter was less 35 years old and the girls whose father was 35 years old or more ( P=0.005, P=0.006). Conclusion:Advanced paternal age was associated with increased risk of ASD in offspring and this effect may be more pronounced in boys.
