Glial cell-targeted strategies for optic nerve protection in glaucoma
10.13389/j.cnki.rao.2025.0155
- VernacularTitle:靶向神经胶质细胞的青光眼相关视神经保护策略
- Author:
Tangren CAI
1
;
Linyi LEI
1
;
Jin YAO
1
Author Information
1. 210000 江苏省南京市,南京医科大学眼科医院
- Publication Type:Journal Article
- Keywords:
ganglion cells;
glial cells;
neuroprotection
- From:
Recent Advances in Ophthalmology
2025;45(11):902-907
- CountryChina
- Language:Chinese
-
Abstract:
Glial cells play a central role in maintaining retinal homeostasis and supporting neuronal function.Under glaucomatous pathological conditions,glial cells become activated in response to neuronal injury,exhibiting a protective bi-as in the early stages while tending to exacerbate damage in the later stages.With in-depth research on the pathogenesis of glaucoma,neuroprotective strategies are gradually shifting from the traditional neuron-centered paradigm to a new para-digm of neuron-glia co-intervention.Targeting the pathological changes in glial cell function and structure,researchers aim to mitigate excitotoxicity and inflammatory damage,optimize energy metabolism,improve tissue remodeling,and reduce myelin loss,thereby protecting retinal ganglion cells.This article reviews recent research progress in providing optic nerve protection through interventions targeting glial cells.These advancements have promoted the development of non-intraocu-lar pressure-dependent neuroprotective strategies.
