Research progress on the effects of assisted reproductive technology to offspring epigenetics
10.3760/cma.j.cn101441-20200806-00428
- VernacularTitle:辅助生殖技术对子代表观遗传影响的研究进展
- Author:
Huitian WANG
1
;
Tao LI
1
;
Jianping OU
1
Author Information
1. 中山大学附属第三医院生殖医学中心,广州 510630
- Publication Type:Journal Article
- Keywords:
Reproductive technique, assisted;
Epigenesis, genetic;
DNA methylation;
Imprinted genes;
Embryonic development
- From:
Chinese Journal of Reproduction and Contraception
2022;42(3):296-300
- CountryChina
- Language:Chinese
-
Abstract:
Although assisted reproductive technology (ART) is an effective method for infertility treatment, its safety deserves great attention. Controlled ovulation stimulation is carried out in the period when the oocyte imprinting gene completes reprogramming, and the in vitro culture of the embryo acts on the sensitive period of imprinting gene demethylation. Intracytoplasmic sperm injection (ICSI) operation will affect the genome, imprinting gene extensive erasure, imprinting reconstruction and maintenance. Gamete and embryo freezing may lead to gene expression disorder, and increase the risk of imprinting genetic diseases. Whether the non-physiological manipulation in ART process will affect the embryos epigenetic regulation program and be further inherited to the next generation needs further investigation. This article reviewed the effects of ART on the epigenetic inheritance of offspring.
