Effects of different gonadotropins in progestin primed ovarian stimulation protocol on ovulation induction of patients with diminished ovarian reserve
10.3760/cma.j.cn101441-20200927-00536
- VernacularTitle:高孕激素状态下促排卵方案中不同促性腺激素对卵巢储备功能低下患者促排卵效果的研究
- Author:
Huiling ZHOU
1
;
Qicai LIU
1
;
Yilu ZOU
1
;
Mei LIAN
1
;
Yujia GUO
1
Author Information
1. 福建医科大学附属第一医院生殖医学中心，福州 350005
- Publication Type:Journal Article
- Keywords:
Diminished ovarian reserve;
Progestin primed ovarian stimulation;
Ovulation Induction;
Follicle-stimulating hormone
- From:
Chinese Journal of Reproduction and Contraception
2021;41(11):980-985
- CountryChina
- Language:Chinese
-
Abstract:
Objective:In order to discuss the ovulation induction effect and clinical significance of human menopausal gonadotropin (hMG) and follicle-stimulating hormone (FSH) on progestin primed ovarian stimulation (PPOS) protocol in patients with diminished ovarian reserve during in vitro fertilization (IVF) cycle. Methods:Using retrospective cohort study method, the patients with diminished ovarian reserve who received PPOS in IVF assisted reproduction in the Reproductive Medicine Center of the First Affiliated Hospital of Fujian Medical University from November 2018 to June 2020 were included, 110 cycles met requirements and were divided into FSH group (63 cycles) and hMG group (47 cycles) according to the different gonadotropin (Gn) used. General information and the outcome of IVF between the two groups were compared.Results:The total number of retrieved oocytes, M Ⅱ oocytes, fertilized oocytes, cleaved oocytes, day 3 (D3) embryos, all freezing embryo, two pronucleus (2PN) fertilization rate, the blastocyst formation rate, day 5 (D5) blastocyst rate and the utilization rate of oocytes, the biochemical pregnancy rate and the miscarriage rate had no statistical differences (all P>0.05). The rate of D3 high-quality embryos, the clinical pregnancy rate and the embryo implantation rate of FSH group were higher than those of hMG group [64.2% (111/173) vs. 50.0% (48/96), P=0.024; 45.8% (22/48) vs. 21.2% (7/33), P=0.023; 36.5% (27/74) vs. 16.7% (8/48), P=0.018] with statistical significances. Conclusion:For patients with diminished ovarian reserve, the rate of D3 high-quality embryos, the clinical pregnancy rate and the embryo implantation rate of FSH group are higher.
