Molecular mechanism of uveal melanoma
10.13389/j.cnki.rao.2025.0144
- VernacularTitle:葡萄膜黑色素瘤发生的分子机制
- Author:
Xiqianru ZHANG
1
;
Yuemei ZHANG
Author Information
1. 730000 甘肃省兰州市,兰州大学第一临床医学院
- Publication Type:Journal Article
- Keywords:
uveal melanoma;
molecular mechanisms;
signaling pathways;
targeted therapy
- From:
Recent Advances in Ophthalmology
2025;45(10):835-840
- CountryChina
- Language:Chinese
-
Abstract:
Uveal melanoma(UM)is the most common primary intraocular malignant tumor in adults,and its patho-genesis is closely related to the abnormal activation of various signaling pathways.This paper systematically summarizes the molecular mechanisms of the Gαq classical signaling pathways(PKC/MAPK/MEK/ERK,PI3K/Akt/mTOR,Trio/Rho/Rac/YAP)and non-classical signaling pathways(TGF-β,Wnt/β-catenin,NF-κB)in UM,explores the interactions between sig-naling pathways,their association with the tumor microenvironment and drug resistance mechanisms,and reviews the lat-est research progress in targeted therapy.This paper systematically elaborates on the regulatory mechanisms of UM signa-ling pathways and their impact on tumor biological behavior,and combines current intervention strategies to provide theo-retical basis and practical guidance for future clinical practice.
